Bone Marrow Transplant
A Bone marrow Transplant / Stem Cell Transplant is a procedure to replace damaged or destroyed Bone marrow with a healthy bone marrow stem cells.
Bone marrow is the soft, fatty tissue inside the bones. The Bone marrows produces blood cell. Stem cells are immature cells in the bone marrow that give rise to all your different blood cell.
There are 3 kinds of Bone Marrow Transplants / Stem Cell Transplants:
- Autologous bone marrow transplant.
- Allogeneic bone marrow transplant.
- Umbilical cord blood transplant.
What is the Common reason for Bone Marrow Transplantation ?
A Bone marrow transplant/ Stem Cell Transplant replaces bone marrow that is either not functioning properly or has been destroyed by chemotherapy or radiation.
Treatments in India
Doctors trust that for many cancers, the donor's white blood cells may attack any remaining cancerous cell, similar to when white cells attack bacteria or viruses when fighting infection.
Our Doctors in India may recommend a Bone Marrow transplant if you have:
- Cancers, such as leukemia, lymphoma, myelodysplasia, and multiple myeloma.
- The Disease that affects the production of Bone marrow cells, such as aplastic anemia, congenital neutropenia, severe immunodeficiency syndromes, sickle cell anemia, and thalassemia.
- Patient had chemotherapy that destroyed your bone marrow.
We Provide the Best Bone Marrow Transplant treatment / Stem Cell Transplantation Treatment in India under the Most Experienced Hematologists in India.
GHN is assisting a huge number of Patients from all over the Globe coming to India for Bone Marrow Transplantation Surgery with best outcome. We are associated with a Team of Best Bone marrow Transplant Doctors in India.
Indian Doctors are very well known for their excellent work in the field of Stem cell Transplants with a very high rate of Success. The Top Doctors for Bone Marrow Transplantation are associated with topmost healthcare institutions in India like Global group of Hospitals, Artemis, Fortis , Max, BLK Super Specialty Hospital Jaypee & Maxcure etc.
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A Bone Marrow Transplant is a procedure which is done to reallocate the ruined Bone Marrow with healthy Bone Marrow stem cells. Bone Marrow is the soft & fatty tissue inside an Individual's Bone. Stem cells are the immature cells in the marrow that helps in rising all Blood Cells in the Human Body.
In India, Healthcare Centers have been Treating Patients suffering from AML, ACL, Thalassemia & other disease related to Bone Marrow of Human Body with great Success. Hospitals like BLK Super Specialty, Fortis, Artemis, Max, Medanta, Global Hospitals & Yashoda Hospitals are treatment a number of Cases for Stem Cell Transplantation with their Team of Experts. Bone Marrow Transplant is a Complex treatment & involves number of phases which patient needs to pass through. The Patients undergoing treatment for Stem Cell Transplantation are very well taken care & Supervised by Team of Doctors, Exclusive Trained Nursing Staff, Paramedical Staff & Patient services Department.
Details about Bone Marrow Transplantation
There are 3 kinds of Bone Marrow Transplantations :
Autologous Bone Marrow Transplant: The word "Auto" means self. Bone Marrow cells are taken from Patient prior receiving high-dose of chemotherapy or Radiation therapy . The Bone Marrow cells are stored in a freezer. Post high-dose chemotherapy or radiation, Stem Cells of the Patient are given back to the body to regenerate normal blood cells which are not infected. In India, Hospital like BLK Super Specialty, Artemis, Medanta, Yashoda & Global Hospitals are doing Autologous Stem Cell Transplantation with very good success rate.
Allogeneic Bone Marrow Transplant: The Word "allo" says others. Bone marrow cells are taken from another person who is also called a Donor. Most of the times, the Donor's genes must atleast match partly with Patient's genes. Blood tests for % of Matching are done to find if a Donor is a good match. Direct Siblings like Brothers & Sisters are mostly found to be good Match. At times parents, children, and other relatives also could be good matches. Donors who are not related may also be found through National Bone Marrow Registries.
Umbilical Cord Blood Transplant: This is a type of Allogeneic Transplantation. Bone Marrow cells are taken from a Newborn Baby's umbilical cord right after Birth. The stem cells are then frozen and preserved until they are required for a Transplant. Umbilical cord blood cells are immature so there is less need for matching. However, Blood counts take longer to recover
Before the Transplant, Chemotherapy, radiation Therapy or both may needed. This may be done in two ways:
Ablative Treatment: High-dose Chemotherapy, Radiation therapy , or both are given to Target & kill any cancerous cells. This also may kill all healthy Bone marrow that remains, and allows new Stem Cells to grow in the Bone marrow.
Reduced Intensity: Treatment also called a mini transplantation: Patients receive lower dose of Chemotherapy before moving ahead for Transplant. This allows old age Patients, and those with other health disorder to have a transplant.
A stem cell transplant is done after Chemotherapy and radiation is completed for the Patient. The Stem Cells are given into Patient's bloodstream usually through a Tube which is called a central venous Catheter. The Process is very much similar to getting a Blood Transfusion. The Stem Cells moves through the blood into the Bone Marrow.
Donor Stem cells can be collected through 2 Ways
Bone marrow Harvesting: This minor procedure which is done under General anesthesia, The donor will be asleep and pain-free during the procedure. The bone marrow is taken away from the back of both hip bones. The amount of marrow taken totally depends on the weight of the person who is recipient.
Leukapheresis: First, the Donor is given 5 days of shots to help Bone Marrow cells travel from the Bone marrow into the blood stream. During leukapheresis, blood is taken from the donor through a IV line in a vein. The portion of of White Blood Cells that contains stem cells is then separated in machine and later given to the recipient. The Red Blood Cells are given back to the donor.
Why is the Procedure Performed?
A Bone Marrow Transplantation reallocates bone marrow that either is not functioning properly or has been ruined (ablated) by Chemotherapy or radiation therapy. Medical Doctors trust that for many cancers, the Donor's White Blood Cells can attach to any remaining Cancer cells, as similar to when white cells attach to bacteria or viruses when fighting an infection.
Bone Marrow Transplantation is suggested when a patient has below mentioned health issues:
- Certain Cancers Like Leukemia, Lymphoma, and multiple Myeloma.
- Diseases Like aplastic anemia, Congenital neutropenia, Severe Immunodeficiency Syndromes, Sickle Cell Anemia, thalassemia.
- Chemotherapy that ruined your Bone Marrow.
Risks of Bone Marrow Transplantation
A bone marrow Transplantation may cause the following symptoms:
Chest pain, Chills, Fever, Flushing, Headache, Nausea, Pain & Shortness of Breath.
Complications of a Bone Marrow Transplant or Stem cell Transplant depend on many things which Include :
- Dosage of Chemotherapy and Radiation Therapy
- Individuals Own Health Status
- Age of Patient
- Matching with Donor
Complications May Include:
- Anemia may be a Complication.
- Bleeding in lungs, Intestines & Brain.
- Clotting in the veins of the liver.
- Damage of kidneys, liver, lungs, and Heart.
- Delayed growth in childrens who accept Bone marrow.
- Graft failures, which meant that the new cells which are put in the Recipient Body do not settle into the body and start producing stem cells.
- Graft-versus-host disease, a condition in which the donor cells attack your own body
- Infections which can be Serious.
- Inflammation and soreness in the mouth, throat, esophagus, and stomach, called mucositis.
- Stomach Disorder, including diarrhea, nausea, and vomitings.
What is done before the Procedure?
Your Doctor would ask about history and do a physical assessment. Patient will have to do many tests before Treatment starts.
A Bone Marrow transplant is usually done in a Hospital or medical center that specializes in such treatment. Most of the time, you stay in a specialized bone marrow Suitsin the center. This is to limit your chance of getting an infection though the Hospital Environment.
Stay in the Hospital depends on how much Chemotherapy or Radiation a Patient receives, the type of Transplantation, and Centers procedures. While Patient is in the hospital, Patient would be isolated because of the increased risk of infection rate. The health Care Team closely monitors blood counts and vital signs with the help of Trained Nursing Staff.
During Your Hospital stay :
- Receiving medications to prevent or treat infections, including antibiotics, antifungals, and antiviral drugs.
- Patient would need many blood transfusions.
- Feeding through a vein (IV) until Patient eat Orally and stomach side effects and mouth sores have gone away, Mouth Sore may come due to Chemotherapy.
- Medications to prevent graft-versus-host disease
How well you do after Transplantation depends on:
- Type of bone marrow transplant.
- How well the Donor's Cells match Patient's Cell.
- The Type of Cancer & illness.
- Age and Overall health.
- Dosage of Chemotherapy or Radiation therapy Patient underwent.
- Any complications.
A Bone marrow Transplant (Stem Cell Transplant) may completely or partially Cure your Sickeness. In case, the transplant is a success, a patient can go back to most of your normal activities as soon he feel well enough. Usually it takes up to 6 to 12 year to recover fully.
We at GHN has treated number of successful cases from different parts of the Globe. We are associated with Topmost Hospitals in India, doing Bone Marrow Transplantation with most advanced Infrastructure