Sickle Cell Anemia Treatment Cost in India

Sickle Cell Anemia Treatment Cost in India

Let us first know about Sickle cell anemia, this  is a group of blood disorders known as sickle cell disease. The Sickle cell disease is an inherited(from parents)red blood cell disorder in which there are not enough healthy RBCs to carry oxygen throughout a human body.

Normally, in general conditions, the flexible, round red blood cells move swiftly through blood vessels. In sickle cell anemia disease, the red blood are shaped like sickles or like a crescent moon. These rigid, sticky cells can get stick in small blood vessels which can slower or even block blood flow and O2 from flowing to other parts of the body.

Symptoms:- 

Signs & symptoms of sickle cell anemia usually appear around 5-6 months of age. They vary one person to another and change over the time. Signs and symptoms can include the following: 

Anemia–  Sickle cells break apart easily and they die, leaving you with too less red blood cells. RBCs usually live for about 120 days before replacement. But these sickle cells usually die in 10-20 days, creating a shortage of red blood cells (anemia).

Without sufficient red blood cells, your body can not get enough oxygen, causing fatigue.

Episodes of pain–  Periodic episodes of pain which are called pain crises, is a major symptom of sickle cell anemia. Pain develops when sickle shape red blood cells block or reduce the blood flow through tiny blood vessels to the chest, abdomen and to joints. Pain can also occur in the bones.

The pain varies and this can last for a few hours to few days or to few weeks. Some people have only a few episodes of pain crises in a year. Others may have a dozen or more pain crises a whole year. A severe pain crisis requires stay in the hospital to manage the pain.

Some adolescents & adults with sickle cell anemia disease also get chronic pain which can result bone and joint damage and ulcers.

Swelling of hands & the feet– The swelling is caused by sickle shape RBCs blocking the blood flow to the hands and to the feet.

Frequent infections – These Sickle cells can damage your spleen, leaving you more exposed to any types of infection. Doctors commonly prescribe infants and children with sickle cell anemia vaccinations & antibiotics to prevent the potentially life threatening infection which is pneumonia.

Delayed growth/puberty– RBCs provide your body with the oxygen (O2) and nutrients needed for your growth. A shortage of healthy red blood cells can reduce or slow down the growth in infants & children and may also delay puberty in teenagers.

Vision Issue– Small blood vessels that supply blood to your eyes can become plugged with these sickle cells. This can damage the retina of the eyes,  the portion of the eye that makes and processes visual images and leads to vision problems.

Incase, you wish to enquire for sickle cell anemia treatment cost in India, Please fee free to contact our Helpline +91 9818857545 or Email us at care@ghnservices.com

Sickle Cell Anemia Treatment Cost in India                              Sickle Cell Anemia Treatment Cost in India

When should you see the Doctor? 

Sickle cell anemia is usually diagnosed in the stage of infancy through newborn screening programs that are run worldwide at all small or big hospitals. If you or your child develops any of the following issues, Please see a doctor right away or you may seek emergency medical care. 

Fever- People with sickle cell anemia disease may have an increased risk of serious infection, and fever/high temperature which can be the first sign of an infection.

  • Unexplained episodes of severe pain such as the pain in abdomen, chest, bones and the joints.
  • Swelling in the hands or the feet.
  • Abdominal swelling, specially if this area is tender to the touch it. 
  • Pale skin or the nail beds.
  • Yellow tint to skin or whites of your eyes.

Signs or symptoms of stroke- If you notice one-sided paralysis or feeling weakness in the face, arms or the legs, confusion, trouble in walking or talking, drastic vision changes or numbness, severe headache. Contact your local doctor incase any of these symptoms. 

For more information on sickle cell anemia treatment cost in India or details on stem cell transplant for sickle cell anemia, Do not hesitate to contact us at +91 9818 857545.

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Cheapest Bone Marrow Transplant in India

Get the cheapest bone marrow transplant in India

Hello Everyone, If you have a loved who is suffering from a disease that requires bone marrow transplant then searching for cheapest  bone marrow transplant in india is a very common as this treatment is expensive and the reason for that is, the patient requiring long hospital stay, use expensive anti cancer medications , continuous observation by doctors and nurses and continuous investigation to check the status of the patient.

The treatment in western countries is so expensive that it is beyond the reach of common man who is not insured, so for bone marrow transplant, India is the best and most suitable choice from people all over the world. 

India is a preferred destination for patients who require bone marrow transplant in India and there are three major factor for this 

1) Expertise 

2) Advanced Technology

3) Cost Effectiveness 

Due to above factors, patients in large number from all over the globe prefer to travel to Indian hospitals for bone marrow transplant. Bone marrow transplant is needed by patients who suffer from Leukemia, Multiple myeloma, lymphoma, sickle cell disease, aplastic anemia and thalassemia etc. The procedure require special arrangements like Special BMT suites to keeping the patients away from any kind of infection, experienced and trained nurses, experienced team of doctors and exclusive arrangements for handling bone marrow transplant patients. 

There are large number of hospitals in India offering bone marrow transplant treatment in india and some of the finest healthcare institutions mentioned below for you to make a choice-

-BLK-Max Super Speciality Hospital

-Artemis Hospitals 

-Fortis Hospitals 

-Apollo Hospitals 

-American Oncology Institute 

Above are some of the top hospitals offering best and cheapest bone marrow transplant in India, Foreign patient from Africa, Middle east, CIS countries, European countries and south Asia travel to India for affordable bone marrow transplant in India. 

 

Process for getting BONE MARROW TRANSPLANT OPINION & Treatment in India– 

1) You need to share medical reports of the patients so that they can be reviewed by top haematologist in India for their expert opinion.

2) Once the opinion is received, Sharing of passport details along with passport details of the donor in case of an allogenic bone marrow transplant to get the Visa Invitation Letter from the treating hospital.

3)Booking for the tickets for travelling to India and sharing them with us for us to make Arrangements for Airport Pick up, Booking of Appointment with Doctor and also arranging for Accomodation.

Incase, Your are looking for options for bone marrow transplant in India, Kindly feel free to get in touch with us. Our Team will be happy to assist you for your treatment in India. 

The cost of bone marrow transplant in India ranges from USD 15000- 45000 depending on the type of transplant is needed by the patient. 

For queries, Please feel free to contact us.

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Cheapest Stem Cell Transplant in India

Cheapest Stem cell transplant in India

Let us first know, what is a bone marrow ?

A bone marrow is found inside bone which is made-up of a sponge like material containing Stem Cell producing blood cells in the human body. There are large number of world class hospitals for cheapest stem cell transplant in india.

Write to us or contact us now for knowing about best hospitals for stem cell transplant in India. GHN acts as a single point of contact for opinion of Top Hematologists (Doctors who  in India.

Let us know about types of Bone marrow Transplantations?

Autologous bone marrow transplantation also called stem cell transplant:  The Stem cell are removed from infected Bone-Marrow before the aggressive medical treatment. These stem cells are kept in freezer and are preserved which are in later time induced into the bone marrow of the patient after Chemotherapy & radiation.

Allogeneic Bone Marrow Transplantation or Allogenic stem cell transplant : The stem cells are removed from a full matched or half matched donor with Patient. Patient & the direct Siblings are required to undergo HLA typing investigations to find out the suitable match for this type of Transplant. The success rate of treatment depends on various factors including % of matching which is considered as one of the vital factor.

Why GHN for cheapest stem cell transplant in India ?

–        Working closely with Top Haematologist in the country.

–        Best treatment packages from various Hospitals.

–        Dedicated Team members for hand holding care on ground.

–        Medical Opinion from Best Hospitals in India.

–        Free Visa Assistance & complete guidance during the process of planning.

–        Complimentary Airport Pick-up facilities

 

Hospitals in India for best and cheapest stem cell transplant in India : –

Dr. Dharma Chaudhary at BLK Hospital is a very well known stem cell transplant specialist in India. BLK Hospital based in New Delhi, the capital city of India does have the Largest Bone Marrow Transplant Unit in India and it is amongst the largest in whole of Asia. We have assisted and offered helped to hundred of Patients from Africa and Middle-East region with successful results of the medical treatment, Bone Marrow Transplant Unit at BLK Hospital does have a 2 Separate floors  with dedicated area and the Staff at BMT Unit does have very experienced nursing and team of specialists. As the supervision is most important aspect when a Patient is undergoing Transplantation phase.

There are many other experienced Haematologists placed at various other leading hospitals in India. We are associated with leading bone marrow transplant centers like Fortis Hospitals, Global Hospitals, Jaypee Hospital, Max Hospitals, KIMS Hospital and American Oncology Institute etc.

Cost of Bone Marrow Transplant in India :

The Hospital partners are offering affordable packages for Bone Marrow Transplantation / Stem cell transplant patients in India. The approximate cost of Allogenic Bone Marrow Transplantation/stem cell transplant ranges from USD 28000 to 39000 in India which depends upon the Individual’s Health and the  response for treatment provided. The Cost of Chemotherapy is excluded if required for Patient before the transplant.  

The approx. cost of autologous bone marrow transplantation range from USD 14000 to USD 21000 in various Hospitals of India.

For Opinion of best stem cell transplant specialists , You may choose to Share clear pictures of  medical Reports on our WhatsApp Helpline No. +91 9818 857545. We will get back with OPINION of Top Experts within 24 hours.

Please note that we provide assistance services at No Extra Cost & Patient need not to pay any additional amount for their treatment here in India

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Best multiple myeloma treatment in India

Best multiple myeloma treatment in India

Multiple myeloma is cancer of the plasma cells (a type of white blood cells) of the bone marrow. Plasma cells are protein-making cells that generally produce the different kinds of antibodies for our immune system. In multiple myeloma, the plasma cells become malicious and cancerous. These myeloma cells stop making different forms of protein in response to the immune system’s needs and instead start to produce a single abnormal type of protein sometimes termed a monoclonal or M protein. Multiple myeloma plasma cell populations accumulate in the bone marrow, and these collections of cells called plasmacytomas can erode the hard outer shell or cortex of the bone that normally surrounds the marrow. These weakened bones show thinning of the bone, as seen in nonmalignant osteoporosis or what appear to be punched out or lytic bone lesions. People often refer to multiple myeloma simply as myeloma (also termed Kahler’s disease after the physician who first described this cancer). The disease usually occurs in people past middle age.

In India, there are large number of options available for Best multiple myeloma treatment in India.

However, rarely it can occur in a child.
One type of myeloma-related plasma cell neoplasm is called a monoclonal gammopathy of undetermined significance (MGUS). In MGUS, medical professionals only find low levels of M protein and people have no symptoms; MGUS infrequently develops into multiple myeloma.

Plasma cell neoplasm is another name for multiple myeloma. Causes of multiple myeloma
What triggers plasma cells into malicious multiple myeloma is unknown. The cancerous
myeloma plasma cells proliferate and crowd out normal plasma cells and can corrode areas of bones. The proteins produced in large amounts can cause many of the symptoms of the disease by making the blood more viscous and depositing the proteins in organs that can interfere with the functions of the kidneys, nerves, and immune system.

Causes of multiple myeloma are not known exactly. But patients more likely to get affected
• older than 65 years
• people of African-American origin
• overweight or obese people
• family member with it

Stages of multiple myeloma

There are four stages of multiple myeloma. While many health care professionals use different staging, these are various stages cited by many clinicians:

• Smoldering: multiple myeloma with no symptoms
• Stage I: early disease with little anemia, relatively small amount of M protein and no
• bone damage
• Stage II: more anemia and M protein as well as bone damage
• Stage III: still more M protein, anemia, as well as signs of kidney damage
Because staging criteria differ according to different groups, some clinicians simply define the individual’s multiple myeloma without assigning a stage and simply estimate a prognosis for their patient.

Symptoms of multiple myeloma

Patients with myeloma may be asymptomatic with an unexplained increase in protein in the
blood. With more advanced disease, some myeloma patients may have weakness due to anemia caused by inadequate production of red blood cells, with bone pain due to the bone damage, and as the abnormal M protein can accumulate and damage the kidneys resulting in patient’s unexplained kidney damage and decreased kidney function. Multiple myeloma cancer cells may be in or outside the bone marrow.

The following symptoms and signs of multiple myeloma – 

• Anemia
• Bleeding
• Nerve damage
• Bone tenderness or pain, including back pain
• Enlarged tongue
• Skin lesions (rash)
• Infections Weakness, fatigue or tiredness
• Kidney failure and/or other end-organ damage• Spinal cord compression •
• Loss of appetite and weight loss
• Leg swelling
• Hypocalcaemia
• Diagnosis of multiple myeloma
• First sign of multiple myeloma is found when a routine blood test shows an abnormal amount of protein in the bloodstream or an unusual stickiness of red blood cells causing them to stack up almost like coins, an unusual formation for red blood cells. The health care professional will do a history and physical exam, looking for signs and symptoms of multiple myeloma. If multiple myeloma is suspected, several studies help confirm the diagnosis.

They include a bone marrow aspiration and biopsy most commonly from the large bones of the pelvis. Cells obtained from the marrow are studied by a pathologist to determine if there is one (plasmacytoma) or more (multiple myeloma) abnormal types or numbers of cells
• Medical professionals also study a sample of the bone marrow aspirate for more detailed
• Characteristics such as the presence or absence of abnormal numbers or types of chromosomes (DNA) by what is called cytogenetic testing.

Bone marrow biopsy can assess the concentrations of cells in the marrow and the presence of abnormal invasive growth of cellular elements.
• Blood testing and urine testing by several methods can determine levels and types of
National Comprehensive Cancer Network (NCCN) recommended that health care professionals use a serum free light chain assay and fluorescence in situ hybridization (FISH) test to further
• Monoclonal protein produced and if there is kidney damage.

Identify multiple myeloma in patients

X-ray studies to identify skeletal lesions and MRI for spinal cord lesions in multiple myeloma.

Medical treatment for multiple myeloma

The therapy is decided based upon the patient’s condition and the cancer management team,
made with the patient’s input. The choices for treatment(s) often include combinations of drugs, some of which medical professionals give as pills and others by intravenous injection.

These include drugs that affect or modulate the immune system, steroids, and some oral or injectable chemotherapy drugs. These are usually used in combinations.
There may be a role for high-dose chemotherapy followed by the administration of bone marrow called a stem cell transplant. Numerous factors come into play in determining whether to do such a transplant. Other medical treatments may include steroids, bisphosphonate therapy, blood or platelet transfusions, plasmapheresis, and other combination therapy depending on the
individual patient’s disease stage.

Radiation therapy may treat painful areas of bone damage. Surgeons can surgically repair broken bones in many cases.

There are many drugs used to treat multiple myeloma. Medical professionals often use the
following drugs in combination with dexamethasone,

• Bortezomib Velcade — protease inhibitor
• Lenalidomide (Revlimid) — immune cell modulation
• Melphalan (Alkeran) — alkylating agent that is toxic to myeloma cells
• Carfilzomib (Kyprolis) — protease inhibitor that is FDA approved usually for patients
• who have failed a previous treatment
• Daratumumab (Darzalex) — monoclonal antibody that may damage or kill multiple
• Myeloma cells (and others) that have CD38 protein on their surface
• Elotuzumab (Empliciti) — a compound that activates the body’s natural killer cells to
• Destroy multiple myeloma cells, usually in combination with Revlimid and Decadron
• Ninlaro (Ixazomib) — This proteasome inhibitor, in combination with Revlimid and
• Dexamethasone, improves the survival rates of some patients with multiple myeloma.

Hospitals offer best multiple myeloma treatment in India, the charges for autologous stem cell transplant ranges between USD 15000 to USD 21000 depending on the status of the disease and individual’s response to the treatment provided at the hospitals.

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About GHN Healthcare –

GHN Healthcare Services is a leading Medical treatment Assistance Company based in New Delhi (National Capital region), India. The Organization actively engaged in providing Medical assistance to foreign Patients who choose to travel to India for quality medical care at a reasonable cost. GHN Healthcare Services is associated with 25+ Top-Notch Hospitals and has a network of 500+ Super Specialists to offer world-class medical care at a reasonable cost.

For any enquiries related to Multiple myeloma treatment in India. Click here…

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Best Lymphoma treatment in India

Are you looking for Lymphoma treatment in India?

Lymphoma is cancer that starts in the lymphocytes, a type of white blood cell of the human immune system. Lymphoma is the most common kind of blood cancer. It includes both Hodgkin’s lymphoma and non-Hodgkin’s lymphoma, depending on the specific type of lymphocyte involved.

 T-cell lymphoma is type of  Non-Hodgkin’s lymphoma  which comes in many forms. 

Types of Lymphoma

  • T-lymphoblastic lymphoma/leukemia:  This disease is very common in teens or young adults, with chances of males being affected more than females. It can be considered either a lymphoma or a type of acute lymphoblastic leukemia (ALL), depending on how much of the bone marrow is involved (leukemias have more bone marrow involvement). 

It often starts in the thymus (a small organ behind the breastbone and in front of the heart, which is where many T cells are made), and may grow into a large tumor in the mediastinum (the area between the lungs). This may cause trouble in breathing and swelling of arms and face.

  • Peripheral T-cell lymphomas:  These are uncommon types of lymphoma that develop from more mature forms of T cells.
  • Adult T-cell leukemia/lymphoma:This lymphoma is caused by infection with a virus called HTLV-1. It  affects the bone marrow (where new blood cells are made), lymph nodes, spleen, liver, skin, and other organs.
  • Cutaneous T-cell lymphomas : These lymphomas start in the skin. Skin lymphomas account for about 5% of all lymphomas.
  • Angioimmunoblastic T-cell lymphoma: This lymphoma accounts for about 4% of all lymphomas. It is more common in old age. It involve  lymph nodes and bone marrow as well as the spleen or liver, which can get enlarged. People with this lymphoma usually have fever, weight loss, skin rashes and often develop infections. 
  • Extranodal natural killer/T-cell lymphoma, nasal type:  This rare type lymphoma  involves the upper airway passages, mostly nose and upper throat, but it can also invade the skin, digestive tract, and other organs. Cells of this lymphoma are similar in some ways to natural killer (NK) cells, another type of lymphocyte.
  • Enteropathy-associated intestinal T-cell lymphoma (EATL):EATL is a lymphoma that grows in the lining of the intestine. This lymphoma is  common in the small intestine, but can also appear in the colon.

This lymphoma occurs in  people with celiac disease (also called gluten-sensitive enteropathy). Celiac disease is an autoimmune disease in which eating gluten, causes the immune system to attack the lining of the intestine and other parts of the body. It is rare among people who have had celiac disease since childhood, and is more common in people diagnosed as older adults. This lymphoma is more common in men than women.

  • Anaplastic large cell lymphoma (ALCL): About 2% of lymphomas are of this type. It is more common in young people (including children), but it can also affect older adults. This type of lymphoma tends to be fast-growing, but many people with this lymphoma can be cured.

There are different forms of Anaplastic large cell lymphoma

  1. Primary cutaneous ALCL only affects the skin. This is discussed in more detail in Lymphoma of the Skin.
  2. Systemic ALCLcan affect the lymph nodes and other organs, including the skin. 

Systemic ALCL is divided into 2 types based on whether the lymphoma cells have a change in the ALK gene. 

ALK-positive and ALK-negative type.

  

SYMPTOMS

 Symptoms vary according to the specific type of T-cell lymphoma.

  • symptoms of mycosis fungoides include:  Patches of flat, scaly skin, thick  raised plaques tumors that may or may not develop into ulcers and itching.
  • Signs and symptoms of Sézary syndrome are: Red, itchy rashes covering most of the body and eyelids. Changes in nails and hair,Enlarged lymph nodes edema, or swelling.

Not all forms of T-cell lymphoma cause symptoms on the skin. Other types may cause:

bleeding or bruising easily

recurrent infections

fevers or chills with no known cause

fatigue

persistent abdominal pain on the left side due to swollen spleen

abdominal fullness

frequent urination

constipation

Treatment of myeloma
 It is very likely to get more than one type of therapy. There are large number of hospitals in india which can be considered best lymphoma treatment hospitals in india. 

Mycosis fungoides and Sézary syndrome may involve direct treatment on the skin as well as systemic treatment.

SKIN TREATMENTS

Certain ointments, creams, and gels applied directly to  skin can control symptoms and even destroy cancer cells. 
Retinoids (vitamin A-derived drugs). Potential side effects are itching, irritation, and sensitivity to sunlight. Retinoids shouldn’t be used during pregnancy.
Corticosteroids. Long-term use of topical corticosteroids can lead to thinning of  skin.
Topical chemotherapy.  It may include redness and swelling. It can also increase the risk of other types of cancer. However, topical chemotherapy tends to have fewer side effects than oral or intravenous chemotherapies.
SYSTEMATIC TREATMENTS 
Medications for T-cell lymphomas include pills, injections, and those given intravenously. Targeted therapies and chemotherapy drugs are often combined for maximum healing. 

 

Systemic treatments may include:

 Chemotherapy combination called CHOP, which includes cyclophosphamide, vincristine, and prednisone
Newer chemo drugs, such as pralatrexate (Folotyn)
Targeted drugs, such as bortezomib (Velcade), belinostat (Beleodaq), or romidepsin (Istodax)
Immunotherapy drugs, such as alemtuzumab (Campath) and denileukin diftitox (Ontak)
In advanced cases, one may need maintenance chemotherapy for up to two years.

Light therapy
UVA and UVB light can kill cancer cells on the skin. Light therapy is usually given several times in a week using special lamps. UVA light treatment is generally combined with drugs called psoralens. UVA light activates the psoralens to kill cancer cells.

Radiation
Radiation therapy uses radioactive particles to destroy cancer cells. The beams can be directed to the affected skin so that internal organs aren’t affected. 

Extracorporeal photopheresis
This is used to treat mycosis fungoides or Sézary syndrome.  Two-day procedure, in which blood will be removed and treated with UV light and drugs that activate when exposed to the light, killing cancer cells. 

Stem cell transplant

In stem cell transplant  bone marrow is replaced with marrow from a healthy donor. 

For more enquiries related to lymphoma treatment in India. Click Here…

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About GHN Healthcare Services 

GHN Healthcare Services is a leading Medical treatment Assistance Company based in New Delhi (National Capital region), India. The Organization actively engaged in providing Medical assistance to foreign Patients who choose to travel to India for quality medical care at a reasonable cost. GHN Healthcare Services is associated with 25+ Top-Notch Hospitals and has a network of 500+ Super Specialists to offer world-class medical care at a reasonable cost.

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BEST MULTIPLE MYELOMA TREATMENT HOSPITALS IN INDIA

BEST MULTIPLE MYELOMA TREATMENT HOSPITALS IN INDIA

It’s such a huge shock when you get to know about suffering from blood cancer. Mr. Kelvin who was about 40 years of age when he got this sad news of having blood cancer disorder, An individual who was living his life with full of joy and happiness around, earning handsome salary with limited responsibilities on his shoulders, however, when he got this news, it was shock of life for him as he never ever thought of such a thing.

As per him, it all started with a back pain and feeling very tired after work, he continued with it for some weeks, months and then over a year however, he never realised the seriousness of the issue as none of us would do if we are in the same stage.

He was staying in Kampala, the capital city of Uganda. During this time he consulted many doctors but none could find out the root cause of it and the problem continued to increase with no improvement in his health. He then decided to consult a Haematologist at Mulago National Referral Hospital on the advice of a doctor.

He underwent a details checkup and it was found that he has multiple myeloma and for which he would need to undergo a Bone marrow Transplant. It was so difficult to digest this shock but it was his friends and family members who supported him at this time of mental distress.

As the transplant was not done in India, the family and friends started searching for BEST MULTIPLE MYELOMA TREATMENT HOSPITALS IN INDIA, Everyone was convinced that India is the most suitable place for his stem cell transplant which he needs to get curative treatment for multiple myeloma.

Finally, the connected with a hospital in New Delhi, the capital city of India. Family got the needed assistance for getting a detailed opinion with cost estimates, Visa invitation letter for the people who were planned to travel with Mr. Kelvin.

Upon arrival they were well received by the team who was coordinating for them and were taken to the Hospital directly without wasting any minute. As per Mr. Kelvin, he was surprised to see the services which were so quick as he got to meet with a very senior haematologist on the first day itself and also did the preliminary examinations.

Doctors in India, planned for his admission for bone marrow transplant after a detailed checkup. He was admitted in the hospital for a time period of about 21 days and got discharged post an Autologous bone marrow transplant which is done for curative care for MULTIPLE MYELOMA.

Mr. Kelvin post discharged was thankful to those who helped him in searching for Best multiple myeloma treatment hospitals in India, as it would have been so very difficult to get a hospital which really has world class treatment and offers services at affordable prices. After a follow up period of about 3 weeks post discharge he was given clearance to fly back to his own country.

On the last day, Mr. Kelvin was heard saying to the team of doctors that he has gotten a new lease of life just because of them and he could not hold his emotions as tears rolled down his eyes. He wrote a wonderful feedback for all the people who were part of this journey of treatment in India.

Today, Mr. Kelvin is living a life back in his country, A life free from blood cancer and living happily and joyfully as he was. 

For more enquires related to BEST MULTIPLE MYELOMA TREATMENT HOSPITALS IN INDIA Click here…

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Best Sickle Cell Disease treatment in India

Best Sickle Cell Disease Treatment in India

What is Sickle cell disease ?

Sickle cell disease is a group of disorders that affects molecule in red blood cells (hemoglobin) that delivers oxygen to cells throughout the body. Person with this disorder have typical hemoglobin molecules called hemoglobin S, which can distort red blood cells into a sickle, or crescent, shape.

What are the symptoms of sickle cell disease?

Symptoms of sickle cell disease usually begin in early childhood. Characteristic features of this disorder include Anemia (low number of red blood cells), repeated infections, and periodic episodes of pain. The severity of symptoms varies from person to person.

The sickle-shaped cells are not flexible and cannot change shape easily. Many of them burst apart as they move through blood vessels.  Sickle cells usually last only for 10 to 20 days, instead of the normal 90 to 120 days. Body may have trouble making enough new cells to replace the ones that is lost.

The signs of sickle cell disease are caused by the sick ling of red blood cells (RBC). When red blood cells sickle, they break down prematurely, which can lead to anemia. Anemia can cause shortness of breath, fatigue, and delayed growth and development in children. The rapid breakdown of red blood cells may also cause yellowing of the eyes and skin, which are signs of jaundice.  A particularly serious complication of sickle cell disease is high blood pressure in the blood vessels that supply the lungs (pulmonary hypertension). Pulmonary hypertension occurs in about one-third of adults with sickle cell disease and can lead to heart failure.sickle cell dsease treatment in India

Types of Sickle Cell Disease

Following are the most common types of SCD:

HbSS

People who have this form of SCD inherit two sickle cell genes (“S”), one from each parent. This is commonly called sickle cell anemia and is usually the most severe form of the disease.

HbSC

People who have this form of SCD inherit a sickle cell gene (“S”) from one parent and from the other parent a gene for abnormal hemoglobin called “C”. Hemoglobin is a protein that allows red blood cells to carry oxygen to all parts of the body. This is usually a milder form of SCD.

HbS beta thalassemia

People who have this form of SCD inherit one sickle cell gene (“S”) from one parent and one gene for beta thalassemia, another type of anemia, from the other parent. There are two types of beta thalassemia: “0” and “+”. Those with HbS beta 0-thalassemia usually have a severe form of SCD. People with HbS beta +-thalassemia tend to have a milder form of SCD.

There also are a few rare types of SCD:

HbSD, HbSE, and HbSO

People who have these forms of SCD inherit one sickle cell gene (“S”) and one gene from an abnormal type of hemoglobin (“D”, “E”, or “O”). Hemoglobin is a protein that allows red blood cells to carry oxygen to all parts of the body. The severity of these rarer types of SCD varies.

Sickle Cell Trait (SCT)

HbAS

People who have SCT inherit one sickle cell gene (“S”) from one parent and one normal gene (“A”) from the other parent. This is called sickle cell trait (SCT). People with SCT usually do not have any of the signs of the disease and live a normal life, but they can pass the trait on to their children. Additionally, there are a few, uncommon health problems that may potentially be related to sickle cell trait

Signs and Symptoms of Sickle Cell diseases

Signs and symptoms of sickle cell disease can be mild or severe enough to require frequent hospitalizations. They may include:

  • Anemia (looking pale)
  • Dark urine
  • Yellow eyes
  • Painful swelling of hands and feet
  • Frequent pain episodes
  • Stunted growth
  • Stroke

Diagnosis

SCD is diagnosed with a simple blood test. It most often is found at birth during routine newborn screening tests at the hospital. In addition, SCD can be diagnosed before birth.

  • Blood counts can reveal an abnormal Hb level in the range of 6 to 8 grams per deciliter.
  • Blood films may show RBCs that appear as irregularly contracted cells.
  • Sickle solubility tests look for the presence of Hb S.

Tests commonly performed to diagnose and monitor patients with sickle cell anemia include:

  • Blood oxygen saturation
  • Complete blood count (CBC)
  • Bilirubin
  • Hemoglobinopathy (Hb) evaluation: There are several methods of evaluating the type and relative amounts of various normal and abnormal hemoglobin types. These methods typically separate the different types of hemoglobin that are present so that they can be identified and quantified. They include:
    • Hemoglobin electrophoresis traditionally used to confirm the diagnosis of sickle cell disease. It measures the different types of hemoglobin in the blood
    • Hemoglobin fractionation by HPLC, the most frequently used method to screen for hemoglobin variants, including Hb S
  • DNA Analysis: Test to investigate alterations and mutations in the genes that produce hemoglobin components. It may be performed to determine whether someone has one or two copies of the Hb S mutation or has two different mutations in hemoglobin genes (e.g., Hb S and Hb C).
  • Blood smear (also called peripheral smear and manual differential): The number and type of red blood cells are evaluated to see if they are normal. Sickle-shaped RBCs may be seen on the blood smear.
  • Iron studies: These may include: iron, ferritin, UIBC, TIBC, and transferrin saturation. These tests measure different aspects of the body’s iron storage and usage. They are ordered to help determine whether someone has an iron deficiency anemia or an excess amount of iron.
  • Serum potassium
  • Sickle cell test

Treatment of Sickle Cell Disease Treatment

The only cure for SCD is  Steam Cell transplantation. Because these transplants are risky and can have serious side effects, they are usually only used in children with severe SCD. For the transplant to work, the bone marrow must be a close match. Usually, the best donor is a brother or sister.

There are treatments that can help relieve symptoms, lessen complications, and prolong life:

  • Antibiotics to try to prevent infections in younger children
  • Pain relievers for acute or chronic pain
  • Hydroxyurea, a medicine that has been shown to reduce or prevent several SCD complications. It increases the amount of fetal hemoglobin in the blood. This medicine is not safe during pregnancy.
  • Childhood immunizations to prevent infections
  • Blood transfusions for severe anemia. If one has some serious complications, such as a stroke,

transfusions are required to prevent more complications. 

Best Sickle Cell Disease treatment in India

Best Sickle cell disease treatment in India have mastered the technology for isolating maximum number of viable stem cells allogenically with the matched donor to treat various patients with SCD. There are various super specialty hospitals with the excellent, well equipped state of the art facility to isolate process and enrich the viable number of stem cells, which can be re infused back into the patient’s body. Generally, these cells are administered through any one of the below mentioned methods depending upon expert’s advice:

  • Local Administration:-Through this mode, cell are infused directly at the targeted site of injury. Thus, in case of cancer of particular organ, cells can be directly infused at the targeted site after prescribed chemotherapy and/or radiotherapy.
  • Intravenous Administration:- Through this mode, cells are infused through the veins to expand blood volumes in the central nervous system, to ensure that the maximum number of cells are reaching to the targeted area.

Thus, once infused back in the body, these cells are known to revamp the cellular system in bone marrow as well as in damaged organs. Thus, the recovery period after the transplant, is found to be between 1 to 2 months; depending upon the patient’s health, age and will power.

The collected data from various clinical trials has suggested that 85 out of 100 children have restructured body’s natural defense mechanism completely after stem cells treatment.

What is the cost of Sickle Cell disease treatment ?

  1. Primary cost would be the cost of the sickle cell transplant in India which will cover the cost of the preliminary conditioning regimes, cost of the actual procedure of transplant and the initial follow up after the procedure. This would range between 28K to 40K USD in India.
  2. The second cost involved is for treating the complications or side effects developed as a result of the sickle cell anemia condition. This would vary from person to person depending on the side effect that the person develops.

Even though best sickle cell disease treatment in India modalities include medication, vaccinations or blood transfusion also, the most effective and permanent solution is a considered to be the sickle cell disease transplant, especially when it is undertaken in children. Hence the primary cost becomes valid for any person looking for a more permanent treatment for sickle cell disease. Transplanting healthy bone marrow to the bloodstream of affected person helps to develop new healthy bone marrow cells which are responsible for developing the new healthy red blood cells. Since the condition is more of a genetic nature autologous transplant is carried out. This is the type of transplant wherein the healthy stem cells from a donor is harvested to plant in the recipient who is suffering from the condition. These new cells start multiplying rapidly to replace/replenish the sickle cells in the body

The cost of best sickle cell disease treatment in India mainly depends on the source of the donor providing the healthy sickle cells. The basic criteria for identifying a potential donor is the HLA matching. First preference is for a donor with an HLA matching from the immediate family. This helps to reduce the risk of rejection. In case a donor is not identified from the family then the next choice is the bone marrow registries worldwide. In India in the absence of a matching donor from the family, the availability of HLA matching donor is first checked in the local bone marrow registry. In case the HLA matching donor has to be sourced from a worldwide registry outside India then the cost of the procedure could move upwards to 60K USD. For more information related to Best Sickle Cell disease treatment in India . Click Here…

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Best Bone Marrow Transplant Hospitals in India

Best Bone Marrow Transplant Hospitals in India

It was a chilly winter morning in the month of July 2018 at Nairobi, the capital city of republic of Kenya. Mr. Paul Karanja who lived about 300 kilometers from Nairobi city, at a place called Eldoret, It is also called the City of Champions. Eldoret is a lovely peaceful rapidly developing city in Kenya. Mr. Karanja was requested by the doctor to come and consult regarding bone marrow aspiration results and that was the reason he travelled to Nairobi on day prior to his appointment at Kenyatta National Hospital.

The treating doctor observed some symptoms and he thought that there was a need of bone marrow aspiration. The report was truly a shock to whole of the family as he was found to have multiple myeloma, a disease which Mr. Karanja did not even know before this day. The doctor was very supportive and he set with the family and was able to calm them down as it was a panic situation for the patient and his family members.

When Mr. Karanja enquired about the treatment of his disease, He was informed that the only treatment for this particular disease is a bone marrow transplant and also he was shared that there is no bone marrow transplant centres in Kenya and he will need to travel abroad for transplant.

Now, the family was restless and they started seeking for best bone marrow transplant hospitals inBone Marrow Transplant Hospitals in India India, some were talking to people who have been in India for treatment, others were talking to friends and everyone was trying to do their self best to come up with some sort of information about best bone marrow transplant Hospitals in India. In one of the family feeling organised on a saturday evening, a lady walked and she was a distant relative of Mr. Karanja,  During the meeting, everyone was trying to contribute sharing views and ideas as to how they move ahead with the process. This old woman said she has been to India for the same treatment and she is doing perfectly well for the last 5 years post bone marrow transplant in India. It was a shock and surprise for everyone sitting in the hall. She said her family kept it confidential as they did not want others to know about her blood cancer. People in kenya take it as a death sentence when someone is diagnosed with any kind of cancer in the current times.

She confidently said to all, that you need not to look for best bone marrow transplant hospitals in India and requested everyone to leave it people who are experts. She promised to connect family with GHN Healthcare who as per her, have experience and needed expertise to help and support patients who are in need of bone marrow transplant in India.

The family was thankful to get this information and they immediately contacted the GHN Team.

The process of searching for a reputable & reliable transplant centre, getting the opinion with tentative cost of treatment, sharing of the visa Invitation letter, arrangement of airport pickup, booking of the accomodation and hand holding care services on ground were offered during their treatment journey of over 2 months in India.

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Best Liver Transplant Hospitals in India

Best Liver Transplant Hospitals in India

It was the most difficult time of my life says the father of Baby Maya Nyambura, Citizen of republic of Kenya (In Swahili it’s Jamhuri ya kenya). Isn’t it the hardest thing in our lives to deal with a situation wherein a family member is seriously ill?  I am certain it is for maximum number of people reading this article, the same was the situation of Mr. Joseph, father to a four year old Baby Maya.

Maya was diagnosed with end stage liver disease also called chronic liver failure in the year Jan 2019 at a hospital in Nairobi, Kenya. The family visited the best of the gastroenterologist in kenya look for possible treatment locally in their own country, every single medic they met gave them whatever best possible they could do for the child, however, it is painful to say that it was not enough. The child needed a treatment which is for extreme conditions and that treatment was liver transplant.

There were multiple meetings organised by the family for discussions related to treatment and  on raising funds for treatment and the day family realised that she doesn’t need anything less than a liver transplant as that was the only option left to save the life of Baby Maya, In the family meeting on a sunday evening at the residence of Mr. Joseph, discussions related to liver transplant happened and all the well wishers present their contributed whatever little they knew about the treatment called liver transplant.

Now, the question how to find best liver transplant hospitals in India, many who were part of the meeting had been to india for some or the other treatments but not specifically for liver transplant. It was a very confusing state for everyone to decide on how to move ahead with process as nobody had a clue about liver transplant hospitals in India.

Liver transplant hospitals in India GHN HealthcareFortunately, one fine day Mr. Joseph visited a local hospital to collect a report of the test which was done few days ago, while he was sitting in the waiting area, he saw a young woman with her kid and the two of them were talking something of India.

Mr. Joseph was in a poor state of mind and body and he had to gather all the courage to ask the woman, Have you been to India Madam? The lady replied with a smiling face ‘yes’, we just came back few days back from New Delhi, India. She told Mr. Joseph that she visited one of the for liver transplant of her child. Mr. Joseph was very excited to know her experience in India and also about the hospital and treatment process in India. He wanted to know which one is the best liver transplant hospitals in India ?

The lady shared contact of GHN Healthcare and said these guys are very professional and experienced to offer you hand holding assistance throughout your treatment journey.

Mr. Joseph was very much relaxeBest liver trasnplant hospitals in indiad to have a reliable contact in India in order to organise for them to get the best hospital, cost, arrangements of visa letter, airport pickup, fixing up appointment and booking for accommodation etc. Once he connected he was guided on steps to follow in order to get the best liver transplant hospitals in India and the process for them was made very easy and swift for them to travel at the earliest for treatment of Baby Maya Nyambura.

Finally, Baby underwent liver transplant surgery at a leading hospital in New Delhi, the capital city of India with some of the world renowned hospital. She got discharged in a stable condition post transplant, stayed in India for a month for the follow ups and then travelled back to Kenya.

Mr. Joseph & the wife wrote an email after going back, Travelling to a strange place is very stressful but when God connects you with reliable, credible and people with good intentions, you feel very light and they make you feel at home. They were incredibly thankful to the whole team of GHN Healthcare for offering them hand holding assistance in India. For more details about Best liver transplant hospitals in India. click here

 

For any enquiry related to “best liver transplant hospitals in India

WhatsApp us  for Liver Transplant Helpline (International Patients): +91 9818857545

You can also mail us at care@ghnservices.com

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Bone Marrow Transplant Cost for T Cell LYMPHOMA- USD 14000 to USD 25000

Cost of Bone Marrow transplant for T Cell LYMPHOMA.

 

What is Lymphoma ?

 

Lymphoma is cancer that starts in the lymphocytes, a type of white blood cell of the human immune system. Lymphoma is the most common kind of blood cancer. It includes both Hodgkin’s lymphoma and non-Hodgkin’s lymphoma, depending on the specific type of lymphocyte involved.

 

T-cell lymphoma is type of  Non-Hodgkin’s lymphoma  which comes in many forms.

 

Types:

  • T-lymphoblastic lymphoma/leukemia:  This disease is very common in teens or young adults, with chances of males being affected more than females. It can be considered either a lymphoma or a type of acute lymphoblastic leukemia (ALL), depending on how much of the bone marrow is involved (leukemias have more bone marrow involvement).

It often starts in the thymus (a small organ behind the breastbone and in front of the heart, which is where many T cells are made), and may grow into a large tumor in the mediastinum (the area between the lungs). This may cause trouble in breathing and swelling of arms and face.

  • Peripheral T-cell lymphomas:  These are uncommon types of lymphoma that develop from more mature forms of T cells.
  • Adult T-cell leukemia/lymphoma:This lymphoma is caused by infection with a virus called HTLV-1. It  affects the bone marrow (where new blood cells are made), lymph nodes, spleen, liver, skin, and other organs.
  • Cutaneous T-cell lymphomas : These lymphomas start in the skin. Skin lymphomas account for about 5% of all lymphomas.
  • Angioimmunoblastic T-cell lymphoma: This lymphoma accounts for about 4% of all lymphomas. It is more common in old age. It involve lymph nodes and bone marrow as well as the spleen or liver, which can get enlarged. People with this lymphoma usually have fever, weight loss, skin rashes and often develop infections.
  • Extranodal natural killer/T-cell lymphoma, nasal type:  This rare type lymphoma  involves the upper airway passages, mostly nose and upper throat, but it can also invade the skin, digestive tract, and other organs. Cells of this lymphoma are similar in some ways to natural killer (NK) cells, another type of lymphocyte.
  • Enteropathy-associated intestinal T-cell lymphoma (EATL):EATL is a lymphoma that grows in the lining of the intestine. This lymphoma is  common in the small intestine, but can also appear in the colon.

This lymphoma occurs in  people with celiac disease (also called gluten-sensitive enteropathy). Celiac disease is an autoimmune disease in which eating gluten, causes the immune system to attack the lining of the intestine and other parts of the body. It is rare among people who have had celiac disease since childhood, and is more common in people diagnosed as older adults. This lymphoma is more common in men than women.

  • Anaplastic large cell lymphoma (ALCL): About 2% of lymphomas are of this type. It is more common in young people (including children), but it can also affect older adults. This type of lymphoma tends to be fast-growing, but many people with this lymphoma can be cured.

There are different forms of Anaplastic large cell lymphoma

  1. Primary cutaneous ALCL only affects the skin. This is discussed in more detail in Lymphoma of the Skin.
  2. Systemic ALCLcan affect the lymph nodes and other organs, including the skin.

Systemic ALCL is divided into 2 types based on whether the lymphoma cells have a change in the ALK gene.

 

ALK-positive and ALK-negative type.

SYMPTOMS

Symptoms vary according to the specific type of T-cell lymphoma.

  • symptoms of mycosis fungoides include:  Patches of flat, scaly skin,thick  raised plaques tumors that may or may not develop into ulcers and itching.
  • Signs and symptoms of Sézary syndrome are: Red, itchy rashes covering most of the body and eyelids. Changes innails and hair,Enlarged lymph nodes edema, or swelling.

Not all forms of T-cell lymphoma cause symptoms on the skin. Other types may cause:

 

bleeding or bruising easily

recurrent infections

fevers or chills with no known cause

fatigue

persistent abdominal pain on the left side due to swollen spleen

abdominal fullness

frequent urination

constipation

 

TREATMENT
It is very likely to get more than one type of therapy, when people are looking for treatment, the major concern the cost of bone marrow transplant for Lymphoma.

Mycosis fungoides and Sézary syndrome may involve direct treatment on the skin as well as systemic treatment.

SKIN TREATMENTS

Certain ointments, creams, and gels applied directly to  skin can control symptoms and even destroy cancer cells.
Retinoids (vitamin A-derived drugs). Potential side effects are itching, irritation, and sensitivity to sunlight. Retinoids shouldn’t be used during pregnancy.
Corticosteroids. Long-term use of topical corticosteroids can lead to thinning of  skin.
Topical chemotherapy.  It may include redness and swelling. It can also increase the risk of other types of cancer. However, topical chemotherapy tends to have fewer side effects than oral or intravenous chemotherapies.
SYSTEMATIC TREATMENTS
Medications for T-cell lymphomas include pills, injections, and those given intravenously. Targeted therapies and chemotherapy drugs are often combined for maximum healing.

 

Systemic treatments may include:

Chemotherapy combination called CHOP, which includes cyclophosphamide, vincristine, and prednisone
Newer chemo drugs, such as pralatrexate (Folotyn)
Targeted drugs, such as bortezomib (Velcade), belinostat (Beleodaq), or romidepsin (Istodax)
Immunotherapy drugs, such as alemtuzumab (Campath) and denileukin diftitox (Ontak)
In advanced cases, one may need maintenance chemotherapy for up to two years.

Light therapy
UVA and UVB light can kill cancer cells on the skin. Light therapy is usually given several times in a week using special lamps. UVA light treatment is generally combined with drugs called psoralens. UVA light activates the psoralens to kill cancer cells.

Radiation
Radiation therapy uses radioactive particles to destroy cancer cells. The beams can be directed to the affected skin so that internal organs aren’t affected.

Extracorporeal photopheresis
This is used to treat mycosis fungoides or Sézary syndrome.  Two-day procedure, in which blood will be removed and treated with UV light and drugs that activate when exposed to the light, killing cancer cells.

Stem cell transplant

 

In stem cell transplant bone marrow is replaced with marrow from a healthy one and the cost of stem cell transplant in India varies from USD 14000 to USD 25000 depending on the individual’s health condition.

 

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